There have been some reports that the Ubi Soft Safe Disc CD protection mechanism causes the game to crash on some systems where it cannot detect a CD-ROM drive.
If that is the case:
(1) Make sure you download 1.01
(2) Contact [email protected] about this.
(3) Post here so that we also know about it.
(4) In a pinch, you can email me at [email protected] if you are interested in trying out an unofficial version that may resolve it.